Betulin is white crystalline powder, while it's Molecular Formula is C30H50O2. white crystalline powder Betulin may be used in the preparation of betulinic acid, which shows anti-HIV, antimalarial and anti-inflammatory activities.

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Quality products?make an important contribution to long-term revenue and profitability. Factory supply good quality Betulin 473-98-3 with stock

1.What is the Betulin ?

crystals

ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.

Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER. At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet. In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice. At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.

2.What is the CAS number for Betulin ?

The CAS number of Betulin is 473-98-3.

3.What are another words for Betulin ?

Synonyms?for?Betulin 473-98-3:Lup-20(29)-ene-3b,28-diol(8CI);Lup-20(30)-ene-3b,28-diol (6CI);3aH-Cyclopenta[a]chrysene,lup-20(29)-ene-3,28-diol deriv.;(+)-Betulin;3,28-Dihydroxy-lupeol;3b,28-Dihydroxylup-20(29)-ene;Betuline;Betulinic alcohol;Betulinol;Betulol;NSC 4644;Trochol;Birch bark Extract;

4.What is Betulin (473-98-3) used for?

Betulin may be used in the preparation of betulinic acid, which shows anti-HIV, antimalarial and anti-inflammatory activities.

InChI:InChI=1/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22?,23?,24-,25?,27-,28+,29+,30+/m0/s1

Relevant articles related to Betulin:

Article	Source
Betulin 3,28-Bis-O-trifluoroacetate: Synthesis and molecular structure	Trishin,Chernyavskii,Shafeeva,Nelyubina , p. 1490 - 1492 (2010)
Anti-tumor betulinic acid derivative and preparation method thereof	- Paragraph 0021-0022, (2021/07/28)
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives	Ren, Yulin,Anaya-Eugenio, Gerardo D.,Czarnecki, Austin A.,Ninh, Tran Ngoc,Yuan, Chunhua,Chai, Hee-Byung,Soejarto, Djaja D.,Burdette, Joanna E.,de Blanco, Esperanza J. Carcache,Kinghorn, A. Douglas supporting information, p. 4452 - 4460 (2018/07/31)

5.Buy Betulin with the best price .

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