URB754 is off-white solid, while it's Molecular Formula is C16H14N2O2. off-white solid URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

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Quality products?make an important contribution to long-term revenue and profitability. Factory supply URB754 86672-58-4 with sufficient production capacity

1.What is the URB754 ?

URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

: 13037-22-4
methyl (N-(4-methylphenyl))dithiocarbamate

: 86672-61-9
Potassium; 2-amino-5-methyl-benzoate

: 86672-58-4
6-Methyl-2-p-tolylamino-benzo[d][1,3]oxazin-4-one

Conditions

Conditions	Yield
With hydrogenchloride; mercury(II) oxide; Yield given. Multistep reaction; 1.) DMF, 5-10 deg C, 4-6 h; 2.) H₂O;

2.What is the CAS number for URB754 ?

The CAS number of URB754 is 86672-58-4.

More information of URB754 86672-58-4 are:

CAS?Number	86672-58-4
Density	1.23 g/cm³
Melting Point	238-240 °C
Boiling Point	434 °C at 760 mmHg
Flash Point	216.3 °C
Vapor Pressure	9.8E-08mmHg at 25°C
Refractive Index	1.627
HS CODE	2934999090
PSA	55.13000
LogP	3.62140
Pka	3.76±0.20(Predicted)

3.What are another words for URB754 ?

Synonyms?for?URB754 86672-58-4:6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one;

4.What is the molecular formula of URB754?

The chemical formula of ?URB754 is?C16H14N2O2 which containing 16 Carbon atoms,14 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??URB754?is 266.299.

5.What is URB754 (86672-58-4) used for?

URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

InChI:InChI=1/C16H14N2O2/c1-10-3-6-12(7-4-10)17-16-18-14-8-5-11(2)9-13(14)15(19)20-16/h3-9H,1-2H3,(H,17,18)

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6.Buy URB754 with the best price .

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