Quality products?make an important contribution to long-term revenue and profitability. OXAMNIQUINE(200MG)DISCONTINUED Good Supplier In Bulk Supply High Purity 21738-42-1

1.What is the OXAMNIQUINE(200MG)DISCONTINUED ?

ChEBI: A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively.

Oxamniquine was originally investigated in the 1960s and was found to have limited antiprotozoal activity, with activity against Schi stosoma mansoni but no activity against the other two schistosomal organisms. In addition, the drug is stage specific, with activity against cercariae and very young schistosomula and adult worms. For reasons that remain unknown, the drug is more effective against adult male worms than against female worms. The drug has structural similarity to hycanthone, which is no longer used because of severe toxicity and teratogenic effects.

2.What is the CAS number for OXAMNIQUINE(200MG)DISCONTINUED ?

The CAS number of OXAMNIQUINE(200MG)DISCONTINUED is 21738-42-1.

3.What are another words for OXAMNIQUINE(200MG)DISCONTINUED ?

Synonyms?for?OXAMNIQUINE(200MG)DISCONTINUED 21738-42-1:6-Quinolinemethanol,1,2,3,4-tetrahydro-2-[(isopropylamino)methyl]-7-nitro- (8CI); (?à)-Oxamniquine;1,2,3,4-Tetrahydro-6-(hydroxymethyl)-2-[(isopropylamino)methyl]-7-nitroquinoline;6-Hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline;Mansil; NSC 352888; Oxamniquine; UK 4261; UK 4271; Vansil

4.What is OXAMNIQUINE(200MG)DISCONTINUED (21738-42-1) used for?

Antischistosomal.

Oxamniquine (Vansil) is a tetrahydroquinoline that stimulates parasite muscular activity at low concentrations but causes paralysis at higher concentrations. The drug may act by esterification and binding of DNA, leading to the death of the schistosome by interruption of its nucleic acid and protein synthesis. The fluke may esterify oxamniquine to produce a reactive metabolite that alkylates parasite DNA. Resistance results from absent or defective esterifying activity of the drug. Oxamniquine has a restricted range of efficacy, being active only against S. mansoni infections. Oxamniquine is given orally and is readily absorbed from the intestinal tract. Peak concentrations in plasma are obtained in about 3 hours. The drug is excreted in urine mostly as a 6-carboxyl derivative. Side effects include CNS toxicity with unsteadiness and occasionally seizures, especially in patients with a history of seizures. It is contraindicated in pregnancy.

InChI:InChI=1/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3

Relevant articles related to OXAMNIQUINE(200MG)DISCONTINUED:

5.Buy OXAMNIQUINE(200MG)DISCONTINUED with the best price .

ShanDong XinDa Chemical CO.,LTD is a quality supplier of OXAMNIQUINE(200MG)DISCONTINUED. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on OXAMNIQUINE(200MG)DISCONTINUED 21738-42-1.