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1.What is the PROCYANIDIN C1 ?
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin that has HIV-related and antioxidant activities. It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 μM and increases NF-κB-dependent transcriptional activity in Jurkat T cells. Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 μg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 μg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 μg/ml). Procyanidin C1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.
Used in Pharmaceutical Applications:
Procyanidin C1 is used as an HIV activator for its ability to activate latent HIV-1 provirus in JLR2 cells at concentrations ranging from 12.5 to 50 μM. This property makes it a potential candidate for the development of therapies targeting HIV.
Used in Antioxidant Applications:
Procyanidin C1 is used as an antioxidant agent for its ability to scavenge 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals, with an IC50 of 3.2 μg/ml. This characteristic highlights its potential use in the development of antioxidant therapies and products.
Used in Enzyme Inhibition:
Procyanidin C1 is used as an inhibitor of α-glucosidase (IC50 = 3.8 μg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 μg/ml). These inhibitory effects suggest its potential application in the development of treatments for diseases related to the overactivity of these enzymes.
Used in Cellular Signaling Modulation:
Procyanidin C1 is used as a modulator of cellular signaling pathways, as it prevents the phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. This property indicates its potential use in the development of therapies targeting various diseases with dysregulated cellular signaling.
2.What is the CAS number for PROCYANIDIN C1 ?
The CAS number of PROCYANIDIN C1 is 37064-30-5.
More information of PROCYANIDIN C1 37064-30-5 are:
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CAS?Number |
37064-30-5 |
|
Density |
1.747g/cm3 |
|
Boiling Point |
°Cat760mmHg |
|
Flash Point |
°C |
|
HS CODE |
29329990 |
|
PSA |
331.14000 |
|
LogP |
4.44390 |
3.What is the molecular formula of PROCYANIDIN C1 ?
The chemical formula of?PROCYANIDIN C1 is C45H38 O18 which containing 45 Carbon atoms,38 Hydrogen atoms and 18 Oxygen atoms,and the molecular weight, and the molecular weight of PROCYANIDIN C1 is 866.786
4.What is PROCYANIDIN C1(37064-30-5)used for?
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin that has HIV-related and antioxidant activities. It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 μM and increases NF-κB-dependent transcriptional activity in Jurkat T cells. Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 μg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 μg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 μg/ml). Procyanidin C1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.
Relevant articles related to PROCYANIDIN C1:
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Article |
Source |
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Synthesis of procyanidins C2 and C1 using lewis acid mediated equimolar condensation |
Oizumi, Yukiko,Katoh, Miyuki,Makabe, Hidefumi,Hattori, Yasunao,Toda, Kazuya,Kawaguchi, Koichiro,Fujii, Hiroshi , p. 2241 - 2250,10 (2020/08/31) |
5.Cost-effective and customizable PROCYANIDIN C1 37064-30-5 supplier
ShanDong XinDa Chemical CO.,LTD is a quality supplier of PROCYANIDIN C1. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on PROCYANIDIN C1 37064-30-5.