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Quality Factory Hot Selling 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-SULFATE SODIUM SALT 4999-79-5 with Fast Shipping
- Molecular Formula: C18H24 O5 S . Na
- Molecular Weight: 374.433
- Melting Point: 207 °C
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- PSA： 95.04000
- Density: g/cm3
- LogP: 3.82340
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-SULFATE SODIUM SALT(Cas 4999-79-5) Usage
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Biochem/physiol Actions |
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease. |
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General Description |
β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women. |
InChI:InChI=1/C18H24O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,17+,18+;/m1./s1
4999-79-5 Relevant articles
Sulfation of various alcoholic groups by an arylsulfate sulfotransferase from desulfitobacterium hafniense and synthesis of estradiol sulfate
Van Der Horst, Michael A.,Van Lieshout, Johan F. T.,Bury, Aleksandra,Hartog, Aloysius F.,Wever, Ron
supporting information, p. 3501 - 3508 (2013/02/22)
Bacterial arylsulfate sulfotransferases ...
Preparation of trifluoroethyl- and phenyl-protected sulfates using sulfuryl imidazolium salts
Desoky, Ahmed Y.,Hendel, Jennifer,Ingram, Laura,Taylor, Scott Douglas
supporting information; experimental part, p. 1281 - 1287 (2011/03/23)
Sulfuryl imidazolium salts (SIS's), a ne...
PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS
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Page/Page column 15-16, (2008/12/07)
The present invention relates to process...
4999-79-5 Process route
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50-28-2
estradiol
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1080-04-2
p-nitrophenyl sulfate
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100-02-7,78813-13-5,89830-32-0
4-nitro-phenol
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4999-79-5
(17β)-3-(sulfooxy)estra-1,3,5(10)-trien-17-ol sodium salt
| Conditions | Yield |
|---|---|
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With
arylsulfate sulfotransferase from Desulfitobacterium hafniense;
In
aq. buffer;
at 30 ℃;
pH=9;
regioselective reaction;
Green chemistry;
Enzymatic reaction;
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57%
|
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-
C20 H25 F3 O5 S
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4999-79-5
(17β)-3-(sulfooxy)estra-1,3,5(10)-trien-17-ol sodium salt
| Conditions | Yield |
|---|---|
|
With
sodium azide;
In
N,N-dimethyl-formamide;
at 70 ℃;
Inert atmosphere;
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94%
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4999-79-5 Upstream products
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50-28-2
estradiol
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865-48-5
sodium t-butanolate
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1080-04-2
p-nitrophenyl sulfate
