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Top quality factory supply 42203-78-1 (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4- at low price

  • Molecular Formula: C11H16 I N O2 . Cl H
  • Molecular Weight: 357.619
  • Vapor Pressure: 2.06E-05mmHg at 25°C 
  • Boiling Point: 361.5°C at 760 mmHg 
  • Flash Point: 172.5°C 
  • PSA: 44.48000 
  • LogP: 3.70040 

(+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-(Cas 42203-78-1) Usage

Biological Activity

Brain penetrant, mixed 5-HT 2A /5-HT 2C receptor agonist (K i values are 0.7, 2.4 and 20 nM for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT 2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)- α .

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

General Description

A Certified Spiking Solution? suited for GC/MS or LC/MS phenethylamine testing applications in forensic analysis, clinical toxicology, or urine drug testing. DOI is a D-substituted amphetamine in the phenethylamine family of hallucinogenic drugs. This designer drug is an extremely potent psychedelic with a long duration of action.

InChI:InChI=1/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H

42203-78-1 Relevant articles

Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane

Glennon,Young,Benington,Morin

, p. 1163 - 1168 (2007/10/02)

The serotonin (5-HT) receptor affinities...

42203-78-1 Process route

(+/-)-N-acetyl-1-(2,5-dimethoxyphenyl)-2-aminopropane
42311-16-0

(+/-)-N-acetyl-1-(2,5-dimethoxyphenyl)-2-aminopropane

4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride
42203-78-1,82830-44-2

4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 2.21 g / silver trifluoroacetate, I2 / CHCl3 / 18 h
2: 71 percent
With iodine; silver trifluoroacetate; In chloroform;
(+/-)-N-acetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane
82830-50-0

(+/-)-N-acetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride
42203-78-1,82830-44-2

4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride

Conditions
Conditions Yield
71%

42203-78-1 Upstream products

  • 82830-50-0
    82830-50-0

    (+/-)-N-acetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

  • 42311-16-0
    42311-16-0

    (+/-)-N-acetyl-1-(2,5-dimethoxyphenyl)-2-aminopropane

42203-78-1 Downstream products

  • 85563-10-6
    85563-10-6

    N,N-dimethyl-2-(4-iodo-2,5-dimethoxyphenyl)isopropylamine

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